| Description | ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells. |
| In vitro | Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins.?Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively.?Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs)[1]. |
| In vivo | Aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases[2]. |
| Animal experiments | Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1]. |
| Synonyms | 芦荟素,葡糖基蒽酮,芦荟大黄素甙, 芦荟苷 |
| molecular weight | N/A |
| CAS | 8015-61-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (119.51 mM) |
| References | 1. Barrantes E , Guinea M . Inhibition of collagenase and metalloproteinases by aloins and aloe gel[J]. Life Sciences, 2003, 72(7):0-850. 2. Na H S , Song Y R , Kim S , et al. Aloin Inhibits Interleukin (IL)‐1β−Stimulated IL‐8 Production in KB Cells[J]. Journal of Periodontology, 2016, 87(6):1-15. |