Aloe-emodin-8-O-β-D-glucopyranoside-product

Description	Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
In vitro	A new lignan glycoside, named 1,5-dihydroxypinoresinol-4'-O-beta-d-glucopyranoside (1), has been isolated from the EtOH extract of the roots of Saussurea lappa, together with twenty known compounds: (+)-1-hydroxypinoresinol-1-O-beta-D-glucopyranoside (2), fraxiresinol-4'-O-beta-D-glucopyranoside (3), (-)-olivil-4''-O-beta-D-glucopyranoside (4), 4-allyl-2,6-dimethoxybenzene-1-O-beta-D-glucopyranoside, syringin, costunolide-15-O-beta-D-glucopyranoside, chlorogenic acid, Aloe-emodin-8-O-beta-D-glucopyranoside (5), rhein-8-O-beta-D-glucopyranoside (6), chrysophanol (7), emodin, dehydrocostus lactone, costunolide, beta-costic acid, reynosin, arbusculin A, alpha-cyclocostunolide, beta-cyclocostunolide, santamarine and magnolialide.
Target activity	PTP1B (human):IC50: 26.6 μM
Synonyms	Aloe-emodin-8-O-beta-D-glucopyranoside, 芦荟大黄素-8-O-β-D-葡萄糖苷
molecular weight	432.38
Molecular formula	C21H20O10
CAS	33037-46-6
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 9 mg/mL (20.81 mM)
References	1. PTP1B inhibitors from Saussrurea lappa.J Asian Nat Prod Res. 2006 Apr-May;8(3):281-6.

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