| Description | Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and Kv4.3 channels at therapeutic concentrations. |
| Synonyms | Cardiorythmine, Raugalline, 阿义吗啉, 阿义马林, Tachmalin, (+)-Ajmaline |
| molecular weight | 326.43 |
| Molecular formula | C20H26N2O2 |
| CAS | 4360-12-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 59 mg/mL(180.8 mM) Chloroform: Soluble |
| References | 1. Fischer F, et al. Inhibition of cardiac Kv1.5 and Kv4.3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action.[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2013, 386(11):991-999. |