Adenosine 5'-diphosphoribose sodium-product

Description	Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+ permeable cation TRPM2 channel activator that also induces autophagy.)
In vitro	在小鼠胚胎成纤维细胞(MEFs)中，H2O2处理表明PARP-1的激活产生了Adenosine 5'-diphosphoribose sodium （ADP ribose），通过细胞外Ca2+流入和（或）溶酶体Ca2+释放促进Ca2+升高。这一过程最终激活早期或晚期自噬，以响应不同程度的氧化应激。[1]
Synonyms	Adenosine 5'-diphosphoribose sodium, ADP ribose sodium
molecular weight	581.3
Molecular formula	C15H22N5NaO14P2
CAS	68414-18-6
Storage	store at low temperature　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 20 mg/mL (34.41 mM), Sonication is recommended. H2O: 100 mg/mL (172.03 mM), Sonication is recommended.
References	1. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62. 2. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5.

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