| Description | Acetylatractylodinol (Tractylodinol acetate) is a natural product isolated from Atractylodes lancea, possesses antioxidant activity. |
| In vitro | 方法与结果：从苍术的根茎中分离得到了一种新的天然产物，2-[(2'E)-3',7'-dimethyl-2',6'-octadienyl]-4-methoxy-6-methylphenol (1)。该化合物对5-脂氧合酶（5-LOX）和环氧合酶-1（COX-1）显示出强烈的抑制效果，但抗氧化活性较弱[IC50 = 0.1微米(5-LOX), 2微米(COX-1), 9微米(PMN/FMLP), 28微米(PMNIOZ)]。此外，还分离并鉴定了五种新的乙炔化合物，分别为(3Z,5E,11E)-tridecatriene-7,9-diynyl-1-O-(E)-ferulate (2), erythro-(1,3Z,11E)-tridecatriene-7,9-diyne-5,6-diyl diacetate (3), (1Z)-atractylodin (4), (1Z)-atractylodinol (5), (1Z)-Acetylatractylodinol (6) 以及已知的(4E,6E,12E)-tetradecatriene-8,10-diyne-1,3-diyl diacetate (7)。结论：在这些乙炔化合物中，仅有2对5-LOX和COX-1活性显示出强烈的抑制作用（IC50 (5-LOX) = 3微米, IC50 (COX-1) = 1微米）。另外，先前已确定具有5-LOX-/COX-1抑制作用的脂肪酸——亚油酸、油酸和棕榈酸——作为正己烷提取物的主要成分被鉴定出来，似乎贡献了该植物体外活性。 |
| Synonyms | Tractylodinol acetate, 乙酰基仓术呋喃烃醇 |
| molecular weight | 240.25 |
| Molecular formula | C15H12O3 |
| CAS | 61582-39-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (249.74 mM) |
| References | 1. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta Med. 2001 Jul;67(5):437-42. 2. Antioxidant activity of constituents from Atractylodes lancea. Pharmaceutical and pharmacological letters,1998,8(2):69-71. |