| Description | Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation. |
| In vitro | Acanthoside B has inhibitory effects on the allergic inflammation[1]. |
| In vivo | Acanthoside B restores the cholinergic activity, decreases the endogenous antioxidant status, suppresses neuroinflammation, and activates the TrkB/CREB/BDNF pathway thereby attenuating Scopolamine inflicted AD-like amnesic traits in mice[2]. |
| Synonyms | 无梗五加苷 B, 刺五加提取物 |
| molecular weight | 580.58 |
| Molecular formula | C28H36O13 |
| CAS | 7374-79-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (86.12 mM) |
| References | 1. Park, Seul-Ki, Lee, Mi-Young. Inhibitory effects of chiisanoside and acanthoside on the allergic inflammation.Molecular and Cellular Toxicology, 2007, 3(4):60-60. 2. Govindarajan Karthivashan, et al. Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway. Food Chem Toxicol. 2019 Jul;129:444-457. 3. Ju Hee Lee, et al. Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. Biomol Ther (Seoul). 2016 Jan;24(1):67-74. |