| Description | Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits inflammatory cytokines by stopping IL-1β, IL-6 and TNF-α production and NF-κB activation in LPS-stimulated alveolar macrophages. |
| Synonyms | NP1302, NP 1302: NP-1302 |
| molecular weight | 302.45 |
| Molecular formula | C20H30O2 |
| CAS | 119290-87-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Qiushi W, Guanghua L, Guangquan X. Acanthoic acid ameliorates lipopolysaccharide-induced acute lung injury. Eur J Pharmacol. 2015 Mar 5;750:32-8. doi: 10.1016/j.ejphar.2015.01.023. Epub 2015 Jan 23. PubMed PMID: 25620130. 2. Wei C, Tan CK, Xiaoping H, Junqiang J. Acanthoic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts. Inflammation. 2015 Apr;38(2):896-901. doi: 10.1007/s10753-014-0051-7. PubMed PMID: 25373915. 3. Bai T, Yao YL, Jin XJ, Lian LH, Li Q, Yang N, Jin Q, Wu YL, Nan JX. Acanthoic acid, a diterpene in Acanthopanax koreanum, ameliorates the development of liver fibrosis via LXRs signals. Chem Biol Interact. 2014 Jul 25;218:63-70. doi: 10.1016/j.cbi.2014.04.016. Epub 2014 May 5. PubMed PMID: 24802811. 4. Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L. Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB. Chem Biol. 2014 Aug 14;21(8):955-66. doi: 10.1016/j.chembiol.2014.06.005. Epub 2014 Jul 24. PubMed PMID: 25065531. |