| Description | 8-hydroxyguanosine (8-OHG) is a marker for measuring the rate of oxidative damage to nucleic acids and lipids. |
| In vivo | 在帕金森病（PD）患者中，脑脊液中8-OHG的浓度约为对照组的三倍。随着疾病持续时间的增长，脑脊液中8-OHG的浓度显著下降。然而，与对照组相比，PD患者血清中8-OHG的浓度没有显著变化。 |
| molecular weight | 299.24 |
| Molecular formula | C10H13N5O6 |
| CAS | 3868-31-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 240 mg/mL (802.03 mM) |
| References | 1. Harman SM, et al. Urinary excretion of three nucleic acid oxidation adducts and isoprostane F(2)alpha measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers. Free Radic Biol Med. 2003 Nov 15;35(10):1301-9. 2. Abe T, et al. Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease. Neurosci Lett. 2003 Jan 16;336(2):105-8. |