| Description | 8-Hydroxyguanine (8 Hydroxyguanine) is the major premutagenic damage produced by reactive oxygen species. It causes G-T and A-C substitutions.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage.8-Hydroxyguanine is mutagenic and carcinogenic and is commonly used in cancer experiments.8-Hydroxyguanine is a biomarker for RNA oxidation and oxidative DNA damage. |
| Synonyms | 8 Hydroxyguanine, 7,8-dihydro-8-oxoguanine, 2-Amino-6,8-dihydroxypurine |
| molecular weight | 167.13 |
| Molecular formula | C5H5N5O2 |
| CAS | 5614-64-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble or slightly soluble) H2O: 3.34 mg/mL (20 mM), when pH is adjusted to 11 with NaOH. Sonication and heating to 45℃ are recommended. Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10. 2. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50. 3. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72. |