| Description | 7-Methoxyrosmanol (7-O-Methylrosmanol) can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity. |
| In vitro | In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid and carnosol) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol and semisynthetic derivatives (7-O-Methylrosmanol, 7-O-ethylrosmanol, and 11,12-O,O-dimethylcarnosol) were prepared. The inhibitory activity of all six compounds against HIV-1 protease was tested. The carnosic acid showed the strongest inhibitory effect (IC90 = 0.08 micrograms/ml). The same compound was also assayed against HIV-1 virus replication (IC90 = 0.32 micrograms/ml). |
| Synonyms | 7ALPHA-甲氧基迷迭香酚, 7-O-Methylrosmanol |
| molecular weight | 360.44 |
| Molecular formula | C21H28O5 |
| CAS | 113085-62-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/mL (33.29 mM) |
| References | 1. Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays.J Nat Prod. 1993 Aug;56(8):1426-30. |