| Description | 6R-Leucovorin is a derivative of Folic Acid. |
| Synonyms | (6R,2'S)-Folinic acid, Dextrofolinic acid |
| molecular weight | 473.44 |
| Molecular formula | C20H23N7O7 |
| CAS | 73951-54-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Liu K, Dai X, Zhong D, Deng P, Ma J, Chen X. Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using solid phase extraction and chiral liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):902-10. doi: 10.1016/j.jchromb.2009.02.046. Epub 2009 Feb 24. PubMed PMID: 19269903. 2. Hempel G, Lingg R, Boos J. Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications. Cancer Chemother Pharmacol. 2005 Apr;55(4):347-353. doi: 10.1007/s00280-004-0910-2. Epub 2004 Oct 21. PubMed PMID: 15723260. 3. Houghton JA, Morton CL, Adkins DA, Rahman A. Locus of the interaction among 5-fluorouracil, leucovorin, and interferon-alpha 2a in colon carcinoma cells. Cancer Res. 1993 Sep 15;53(18):4243-50. PubMed PMID: 8364921. 4. Patel R, Newman EM, Villacorte DG, Sato JK, Reaman GH, Finklestein JZ, Krailo MD, Hammond GD, Holcenberg JS. Pharmacology and phase I trial of high-dose oral leucovorin plus 5-fluorouracil in children with refractory cancer: a report from the Children's Cancer Study Group. Cancer Res. 1991 Sep 15;51(18):4871-5. PubMed PMID: 1893377. |