6-O-Nicotinoylscutebarbatine G-product

Description	6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 2.1 5.7 μM.
In vitro	The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-Nicotinoylscutebarbatine G (7) and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values[1]
molecular weight	576.64
Molecular formula	C32H36N2O8
CAS	1206805-30-2
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-stimulated Microglial Cells.Chem Biodivers. 2017 Aug 14

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