| Description | 6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. 6-Hydroxyflavanone has anti-injury sensory properties in a streptozotocin-induced diabetic neuropathy model. in a streptozotocin-induced diabetic neuropathy model with anti-injury sensory properties. |
| In vivo | 6-Hydroxyflavanone (6-HF) (6-HF) (5, 30, and 60 mg/kg ) inhibited the COX-2 and 5-LOX enzymes significantly. It substantially reduced heat nociception in a hot plate analgesia meter, as well as carrageenan-induced paw edema in rodent models. The authors discovered that 6-HF exhibited anti-nociception properties in a streptozotocin-induced diabetic neuropathy (DIN) model. According to the findings of this study, 6-HF demonstrated the ability to diminish inflammation caused by diabetes, as well as to exert an anti-nociceptive.[3] |
| Target activity | Androgen receptor:3.3 µM |
| molecular weight | 240.25 |
| Molecular formula | C15H12O3 |
| CAS | 4250-77-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.4 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Nishizaki Y, et al. Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009;19(16):4706-4710. 2. Akbar S, et al. Targeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone. Nutrients. 2023;15(11):255 |