| Description | 5-Methoxytryptophol (2-(5-Methoxy-1H-indol-3-yl)ethanol) is a pineal indoleamine derived from serotonin shown to be biologically active in a number of species. |
| In vitro | 在MC3T3-E1细胞中，大多数5-Methoxytryptophol 浓度略微降低了成骨细胞的代谢活性。细胞培养14天后，Rankl mRNA水平下降。5-Methoxytryptophol还促进高水平的骨钙素分泌和矿化能力。在RAW264.7细胞中，5-Methoxytryptophol降低了成骨细胞的数量和活性。5-Methoxytryptophol 通过ERK磷酸化促进了ERK1/2通路的激活，而LUZ的添加则抑制了这一效应。总之，5-Methoxytryptophol 抑制了成骨细胞的生成，并促进了成骨细胞分化[3]。 |
| Synonyms | 2-(5-Methoxy-1H-indol-3-yl)ethanol, Methoxytryptophol, 5-甲氧基色醇 |
| molecular weight | 191.23 |
| Molecular formula | C11H13NO2 |
| CAS | 712-09-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 88 mg/mL (460.18 mM) |
| References | 1. Ouzir M, Bouhaddou N, Khalki H, Lakhdar-Ghazal N. Physiological and pharmacological properties of 5-methoxytryptophol. Expert Rev Endocrinol Metab. 2013 Jul;8(4):355-364. 2. Raynaud F, et al. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin after 5-methoxytryptamine administration of golden hamsters: physiological implications. J Neural Transm Gen Sect. 1991;84(1-2):33-43. |