| Description | 5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine in DNA. Hydroxymethyl-2'-deoxycytidine replication fork instability is associated with the presence of poly(ADP-ribose) polymerase 1 (PARP1) on chromatin. |
| Synonyms | 5hmdC, 2'-脱氧-5-(羟甲基)胞啶 |
| molecular weight | 257.24 |
| Molecular formula | C10H15N3O5 |
| CAS | 7226-77-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25.72 mg/mL (100 mM), Sonication is recommended. |
| References | 1. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. 2. Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9. |
5-Hydroxymethyl-2'-deoxycytidine
CAS No.: 7226-77-9
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA dama
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