| Description | 5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential. |
| In vitro | The best in vitro trypanocidal activity for T. brucei rhodesiense was exerted by 7,8-dihydroxyflavone (50% inhibitory concentration [IC50], 68 ng/ml), followed by 3-hydroxyflavone, rhamnetin, and 7,8,3',4'-tetrahydroxyflavone (IC50s, 0.5 microg/ml) and catechol (IC50, 0.8 microg/ml).?The activity against T. cruzi was moderate, and only Chrysin dimethylether and 3-hydroxydaidzein had IC50s less than 5.0 microg/ml. |
| molecular weight | 282.29 |
| Molecular formula | C17H14O4 |
| CAS | 21392-57-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (177.12 mM) |
| References | 1. Tasdemir D . Antitrypanosomal and antileishmanial activites of flavoids and their analogues : In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies[J]. Antimicrob Agents Chemother, 2006, 50(4):1352-1364. |