| Description | 1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal . 3. 5,7-Dihydroxychromone induces the translocation of Nrf2 to the nucleus and increases Nrf2/ARE binding activity which results in the up-regulation of the expression of Nrf2-dependent antioxidant genes, including HO-1, NQO1, and GCLc. |
| Synonyms | 5,7-Dihydroxy-4H-Chromen-4-One, 5,7-二羟基色酮, 5,7-二羟基色原酮 |
| molecular weight | 178.14 |
| Molecular formula | C9H6O4 |
| CAS | 31721-94-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (280.67 mM) |
| References | 1. Kim D W , Lee K T , Kwon J , et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway[J]. Life Sciences, 2015, 130:25-30. |