| Description | 4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. |
| In vitro | 4'-Methoxyresveratrol significantly abated the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome including NLRP3 and cleaved caspase-1 and reduced the secretion of mature IL-1β. The anti-inflammatory effect of 4'-Methoxyresveratrol is mainly through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation. 4'-Methoxyresveratrol could be a novel therapeutic agent for inflammation-related diseases. |
| Synonyms | 白藜芦醇-4'-甲醚, 4'-O-Methylresveratrol |
| molecular weight | 242.27 |
| Molecular formula | C15H14O3 |
| CAS | 33626-08-3 |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 48 mg/mL (198.13 mM) |
| References | 1. Wenzhe Y , Mengru T , Yueliang Z , et al. 4′-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway[J]. Molecules, 2018, 23(6):1447-. |