| Description | 4-methoxylonchocarpin was isolated from the roots of Abrus precatorius as a potent anti-inflammatory compound. 4-methoxylonchocarpin inhibited NF-κB-activated TNF expression by inhibiting the binding of LPS to TLR4 in macrophages and suppressed TNBS-induced colitis in mice. |
| In vitro | Abrus precatorius（AP, Fabaceae）的根在越南和中国传统上用于治疗炎症性疾病，如口炎、哮喘、支气管炎和肝炎。本研究中，我们分离出4-methoxylonchocarpin (ML)。在脂多糖（LPS）刺激的巨噬细胞中，ML通过抑制LPS与Toll样受体4 (TLR4)的结合，进而抑制核因子（NF）-κB的激活以及肿瘤坏死因子（TNF）和白细胞介素（IL）-6的表达，发挥了作用。[1] |
| In vivo | 小鼠口服4-methoxylonchocarpin(ML)可抑制TNBS引起的结肠炎，表现为减少结肠缩短和结肠中髓过氧化物酶活性的降低。ML处理显著抑制了核因子(NF)-κB的活化和结肠中转化生长因子β激活的激酶1的磷酸化。此外，ML处理还抑制了TNBS诱导的IL-1β、IL-17A和TNF的表达。同时，ML降低了TNBS诱导的M1型巨噬细胞标记物如精氨酸酶-2和TNF的表达，而增加了M2型巨噬细胞标记物如精氨酸酶-1和IL-10的表达。总之，ML通过抑制LPS与免疫细胞上的TLR4的结合并增加M1型巨噬细胞向M2型巨噬细胞的极化，减轻了小鼠的结肠炎。[1] |
| molecular weight | 336.38 |
| Molecular formula | C21H20O4 |
| CAS | 51589-67-4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017;45:90-97. 2. Li J, Kang Z, et al. Potent insecticidal activity of Eleocharis dulcis (Burm. f.) Trin peel extract and its main components against aphids. Pest Manag Sci. 2023;79(4):1295-1304. 3. Ngadjui BT, et al. Prenylated flavonoids from the aerial parts of Dorstenia mannii. Phytochemistry. 2000;55(8):915-919. 4. Hussain H, et al. 4-Benzyloxylonchocarpin and Muracatanes A-C from Ranunculus muricatus L. and Their Biological Effects. Biomolecules. 2020;10(11):1562. |