| Description | 4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer |
| In vitro | 4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis. Mechanistically, 4-AC blocked the increase of cellular ROS induced by oxidative stress, and upregulated NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor. The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. The tBHQ, an NRF2 stabilizer, consistently mimicked the protective effect of 4-AC against tBHP-induced RPE death[1]. |
| molecular weight | 152.15 |
| Molecular formula | C8H8O3 |
| CAS | 3233-32-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (197.18 mM) |
| References | 1. Jakub H , Alexander K , Julia C , et al. 4-Acetoxyphenol Prevents RPE Oxidative Stress–Induced Necrosis by Functioning as an NRF2 Stabilizer[J]. Invest Ophthalmol Vis, 2015, 56(9):5048-5059. 2. Li T , Berberich J , Sahle-Demessie E , et al. A disposable acetylcholine esterase sensor for As( iii ) determination in groundwater matrix based on 4-acetoxyphenol hydrolysis[J]. Analytical Methods, 2019, 11(40):5203-5213. |