| Description | 4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity. |
| In vitro | 4-Hydroxyderricin （100µM）抑制了LLC细胞的DNA合成，但对人脐静脉内皮细胞（HUVECs）的DNA合成或LLC细胞对HUVECs的粘附无影响。4-Hydroxyderricin （每日两次，每次50mg/kg）抑制去瘤小鼠脾脏中淋巴细胞、CD4+、CD8+以及自然杀伤（NK）-T细胞数量的减少。[2] |
| In vivo | 4-Hydroxyderricin （每日两次，每次50 mg/kg；口服）抑制皮下植入的LLC小鼠的肿瘤生长。在通过手术切除皮下肿瘤后，4-Hydroxyderricin 抑制了肺转移并延长了小鼠的生存时间。[2] 4-Hydroxyderricin （10至100微米）阻止了HUVECs在Matrigel中形成类似毛细血管的管状结构。[2] 口服4-Hydroxyderricin 能保持皮下植入LLC的小鼠的脾脏和胸腺重量接近正常小鼠的水平。[2] |
| Target activity | MAO-B:3.43 μM |
| molecular weight | 338.4 |
| Molecular formula | C21H22O4 |
| CAS | 55912-03-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (266.0 mM), Sonication is recommended. |
| References | 1. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. 2. Kimura Y, et al. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 2004;70(3):211-219. 3. Sumiyoshi M, et al. Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages. Phytomedicine. 2015;22(7-8):759-767. 4. Akihisa T, et al. 4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells. J Oleo Sci. 2011;60(2):71-77. 5. Nakamura T, et al. Absorption and metabolism of 4-hydroxyderricin and xanthoangelol after oral administration of Angelica keiskei (Ashitaba) extract in mice. Arch Biochem Biophys. 2012;521(1-2):71-76. |