| Description | 4-Hydroxybenzoic acid (4-hydroxybenzoate) is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols. It could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL. |
| Target activity | Antibacterial:160 μg/mL (IC50) |
| Synonyms | p-hydroxybenzoic acid, para-Hydroxybenzoic acid, PHBA, 对羟基苯甲酸, 4-hydroxybenzoate |
| molecular weight | 138.12 |
| Molecular formula | C7H6O3 |
| CAS | 99-96-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (398.2 mM) |
| References | 1. Farhoosh R, et al. Food Chem. 2016 Mar 1;194:128-34. 2. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051. 3. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784. |