| Description | 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (administered orally has shown good tolerability and good intestinal absorption. 3β-Ursodeoxycholic acid can undergo enzymatic isomerization in the intestine and liver and produce UDCA. |
| In vivo | Isoursodeoxycholic acid (2,500 mg/kg in the diet) decreases serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transaminase (ALT) levels in bile duct-ligated rats but does not affect liver histology.[3] |
| Synonyms | Isoursodeoxycholic acid |
| molecular weight | 392.57 |
| Molecular formula | C24H40O4 |
| CAS | 78919-26-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (229.3 mM), Sonication is recommended. |
| References | 1. Marschall HU, et al. Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis. J Lipid Res. 2001;42(5):735-742. 2. Beuers U, et al. Formation of iso-ursodeoxycholic acid during administration of ursodeoxycholic acid in man. J Hepatol. 1991;13(1):97-103. 3. Purucker E, et al. Metabolism and effects on cholestasis of isoursodeoxycholic and ursodeoxycholic acids in bile duct ligated rats. Biochim Biophys Acta. 2001;1526(1):44-52. 4. Marschall HU, et al. Study of human isoursodeoxycholic acid metabolism. J Hepatol. 1997;26(4):863-870. |