3-Oxotirucalla-7,24-dien-21-oic acid-product

Description	3-Oxotirucalla-7,24-dien-21-oic acid is the first known compound isolated from Polygonum spp. and can be obtained from the roots of Black Cohosh. 3-Oxotirucalla-7,24-dien-21-oic acid showed potent cytotoxicity against MCF-7 cell lines.
In vitro	3-Oxotirucalla-7,24-dien-21-oic acid 从 Luvunga scandens (Roxb.) Buch-Ham ex Wight & Arn, Rutaceae 的二氯甲烷提取物中分离得到。通过MTT测定法评估了3-Oxotirucalla-7,24-dien-21-oic acid 对人乳腺腺癌细胞系(MCF-7)的细胞毒性潜力。结果显示，3-Oxotirucalla-7,24-dien-21-oic acid 对MCF-7细胞系表现出强烈的细胞毒性，IC50值分别为27.5 μM，从而表明其作为抗肿瘤剂的潜力。[1]
Target activity	HIV-1:20 microg/mL, MCF-7 cells:27.5 μM
molecular weight	454.68
Molecular formula	C30H46O3
CAS	82464-35-5
Storage	store at low temperature,keep away from direct sunlight　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
References	1. Al-Zikri P N H, et al. Cytotoxic tirucallane triterpenes from the stem of Luvunga scandens. Revista Brasileira de Farmacognosia. 2014 ; 24(5):561-564. 2. Ma C, et al. Inhibitory effects on HIV-1 protease of constituents from the wood of Xanthoceras sorbifolia. J Nat Prod. 2000 ; 63(2):238-242. 3. Leutcha BP, et al. Cytotoxicity of a new tirucallane derivative isolated from Stereospermum acuminatissimum K. Schum stem bark. Nat Prod Res. 2021 ; 35(22):4417-4422.

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