| Description | 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could protect patients with xanthinuria from the development of renal xanthine calculi. |
| In vitro | 3-Methylxanthine（3-MX）在 20 mg/L 时显著地抑制黄嘌呤结晶。3-Methylxanthine 是 TB 的主要代谢产物。 |
| Target activity | GMP:920 μM (IC50) |
| molecular weight | 166.14 |
| Molecular formula | C6H6N4O2 |
| CAS | 1076-22-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | 1M NaOH: 50 mg/mL (300.95 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommended. DMSO: 2.61 mg/mL (15.71 mM), Sonication is recommended. |
| References | 1. Xanthine urolithiasis: Inhibitors of xanthine crystallization. PLoS One. 2018 Aug 29;13(8):e0198881. |