| Description | 3-Isomangostin is an acetylcholinesterase selective inhibitor and a potent human aldose reductase inhibitor with an IC50 of 3.48 uM. 3-Isomangostin has free radical scavenging activity and inhibits MutT homolog 1 (MTH1) with an IC50 of 52 nM. It shows antiplasmodial activity with an IC50 values in the range of 4.71-11.40 uM. 3-Isomangostin can be used to develop anticancer agents as well. |
| In vitro | Species of Garcinia have been used to combat malaria in traditional African and Asian medicines, including Ayurveda. In the current study, we have identified antiplasmodial benzophenone and xanthone compounds from edible Garcinia species by testing for in vitro inhibitory activity against Plasmodium falciparum. Whole fruits of Garcinia xanthochymus, G. mangostana, G. spicata, and G. livingstonei were extracted and tested for antiplasmodial activity. Garcinia xanthochymus was subjected to bioactivity-guided fractionation to identify active partitions. Purified benzophenones (1-9) and xanthones (10-18) were then screened in the plasmodial lactate dehydrogenase assay and tested for cytotoxicity against mammalian (Vero) cells. The benzophenones guttiferone E (4), isoxanthochymol (5), and guttiferone H (6), isolated from G. xanthochymus, and the xanthones α-mangostin (15), β-mangostin (16), and 3-Isomangostin (17), known from G. mangostana, showed antiplasmodial activity with an IC50 values in the range of 4.71-11.40 μM. Artemisinin and chloroquine were used as positive controls and exhibited an IC50 values in the range of 0.01-0.24 μM. |
| Target activity | MTH1:52 nM |
| molecular weight | 410.46 |
| Molecular formula | C24H26O6 |
| CAS | 19275-46-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 40mg/mL (97.45mM) DMSO: 40mg/mL (97.45mM) |
| References | 1. In vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species. Planta Med. 2014 Jun;80(8-9):676-81. 2. Health and Wellness Product from Mangosteen (Garcinia mangostana L.) Rind: Bioactive Potentials. International Journal of Biotechnology for Wellness Industries, 2015, 3(4):111-20. |