| Description | 3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level. |
| In vitro | 3-DSC inhibited viral genomic replication and transcription only at a relatively high concentration. We then evaluated the effect of 3-DSC on the regulation of virus-induced cellular apoptosis. 3-DSC ameliorated virus-induced DNA fragmentation in a concentration-dependent manner, which tends to be a consequence of its inhibition of upstream caspase activation. 3-DSC also protected host cells against influenza-induced inflammation by suppressing CCL5 and CXCL10 secretions in endothelial cells and reducing the production of IL-6 and IL-1β in monocytes/macrophages. |
| Target activity | H3N2:1.06 μM (IC50) |
| molecular weight | 270.28 |
| Molecular formula | C16H14O4 |
| CAS | 112408-67-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation.Planta Med. 2012 Jun;78(10):968-73. |