| Description | 3-Carene（Delta-3-Carene） is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infiltrates and COX-2 overexpression induced by nociceptive stimuli.3-Carene has anti-injury properties and promotes the activity and expression of alkaline phosphatase, an early marker of osteoblast differentiation. |
| In vitro | 大鼠肺泡巨噬细胞在培养基中与单萜3-Carene(浓度分别为0、0.005、0.05、0.5和5.0 μM; 暴露时间为75分钟; 用大鼠肺泡巨噬细胞)孵育75分钟。细胞活力与3-Carene浓度之间存在剂量依赖性关系。在3-Carene浓度为5.0 μM时，98%的AM死亡。AM对热灭活酵母颗粒的吞噬作用显著减少，而颗粒在细胞表面的附着则在0.5 μM 3-Carene浓度下显著增加。在0.5 μM 3-Carene作用下，约50%的AM缺少或几乎无表面突起。因此，3-Carene主要影响颗粒的包围作用。作为Curosurf的表面活性剂（0.5 mg/ml）加入孵育介质中，对AM对3-Carene暴露的反应无影响。[1] |
| Synonyms | Delta-3-Carene |
| molecular weight | 136.23 |
| Molecular formula | C10H16 |
| CAS | 13466-78-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (367.03 mM) |
| References | 1. Johansson A, et al. Effects of low concentrations of 3-carene on alveolar macrophages in vitro. Toxicology. 1997 Jun 27;120(2):99-104. 2. Jeong JG, et al. Low concentration of 3-carene stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Phytother Res. 2008 Jan;22(1):18-22. |