| Description | 2-Hydroxybutyric acid (α-Hydroxybutyric acid) is a product of protein metabolism and a biomarker for type 2 diabetes and pre-eclampsia. |
| In vitro | 2-Hydroxybutyric acid（0-40 mM；24-48小时）可以减少对 AML12、BRL3A 和小鼠原代肝细胞的 AP 诱导毒性[3]。 |
| In vivo | 2-Hydroxybutyric acid （250 mg/kg；i.p. 3d）预防了 C57 小鼠中 AP 诱导的肝损伤[3]。 |
| Synonyms | α-Hydroxybutyric acid |
| molecular weight | 104.1 |
| Molecular formula | C4H8O3 |
| CAS | 600-15-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (480.31 mM), Sonication is recommended. |
| References | 1. Landaas S, et al. The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta. 1975 Jan 6;58(1):23-32. 2. Shantavasinkul PC, et al., Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surg Obes Relat Dis. 2018 Aug;14(8):1126-1132. 3. Zheng N, et al., Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. J Pharm Anal. 2020 Dec;10(6):560-570. |