| Description | 2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer. |
| In vitro | 2-Hydroxy-3-methoxy chalcone（TJ3）（10 µM和25 µM）显著降低了SW480癌细胞释放ICAM-1的量。对于由SW480和SW620癌细胞系释放的VCAM-1，其没有明显影响。然而，该化合物在减少SW480细胞中的MIF浓度方面展现出了显著的剂量依赖性降低。此外，25 µM浓度的TJ3显著降低了SW480和SW620癌细胞分泌IL-8的水平。这些结果表明，所测试的TJ3对结肠癌细胞展示出调控作用。[1] |
| Target activity | mTOR:21 µM |
| molecular weight | 254.28 |
| Molecular formula | C16H14O3 |
| CAS | 7146-86-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (176.97 mM) |
| References | 1. Bronikowska J, et al. The modulating effect of methoxy-derivatives of 2'-hydroxychalcones on the release of IL-8, MIF, VCAM-1 and ICAM-1 by colon cancer cells. Biomed Pharmacother. 2022;145:112428. 2. Roy T, et al. Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers. Bioorg Chem. 2021;107:104595. |