| Description | 2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis through the action of endothelial endothelial NO synthase.2-Ethylpyrazine induces vasodilation by inducing NO release and increasing peripheral blood flow to induce vasodilation. |
| In vitro | 2-ethylpyrazine (2-EP) (100 µM or 1 mM) induces vasodilatation through the activities of endothelium-derived relaxing factors. 2-EP activates NO synthesis through the effect of endothelial NO synthase in the endothelium. As a result, cyclic GMP levels rise in smooth muscle cells and vasodilatation is induced.[1] |
| In vivo | 2-ethylpyrazine (2-EP) (10, 100 μg/kg; injected; Wistar rats ) increases peripheral blood flow in rats.[1] |
| molecular weight | 108.14 |
| Molecular formula | C6H8N2 |
| CAS | 13925-00-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (832.3 mM), Sonication is recommended. |
| References | 1. Ashigai H, et al. 2-Ethylpyrazine Induces Vasodilatation by Releasing Nitric Oxide in the Endothelium. Biol Pharm Bull. 2017;40(12):2153-2157. |