2,3-Dihydroxy-4-methoxyacetophenone-product

Description	2,3-Dihydroxy-4-methoxyacetophenone (2',3'-Dihydroxy-4'-methoxyacetophenone) is a natural product,it improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
In vivo	通过口服给予斯考波拉明诱导失忆的小鼠2,3-Dihydroxy-4-methoxyacetophenone(1, 10, 20, 40 和 50mg/kg)，在Morris水迷宫测试中，2,3-Dihydroxy-4-methoxyacetophenone(50mg/kg)能改善斯考波拉明引起的空间记忆损伤。2,3-Dihydroxy-4-methoxyacetophenone以剂量依赖性方式保护HT22细胞免遭谷氨酸诱导的细胞死亡(EC50值：10.94μM)。此外，2,3-Dihydroxy-4-methoxyacetophenone被发现能抑制HT22细胞中[Ca(2+)]的积累，并具有抗氧化活性。通过其抗氧化活性，2,3-Dihydroxy-4-methoxyacetophenone发挥神经保护和认知增强作用。2,3-Dihydroxy-4-methoxyacetophenone改善认知功能，可能有助于阿尔茨海默病的治疗。
Synonyms	2',3'-Dihydroxy-4'-methoxyacetophenone, 2,3-二羟基-4-甲氧基苯乙酮水合物
molecular weight	182.17
Molecular formula	C9H10O4
CAS	708-53-2
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 22.5 mg/mL (123.51 mM)
References	2. Weon J B , Ko H J , Ma C J . The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23(24):6732-6736.

PeptideDB