| Description | 1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound in Black Walnut Kernels. It shows anti-inflammatory activity. |
| In vitro | The compounds were isolated by silica gel column chromatography, Sephadex LH-20 column chromatography and ODS column chromatography.Their structures were elucidated by spectral analyses and physicochemical properties. The anti-inflammatory activities of selected isolated compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cell lines by Griess reaction. Eight compounds were obtained from n-butanol fraction oi Mangifera indica L. seed kernel, whose structures were elucidated as 4-O-ethylgallic acid (1), gallic acid (2), citric acid(3), 1,2,3,4,6-penta-O-galloylglucose(4),1,3,6-Tri-O-galloylglucose(5), hyperoside(6), quercetin-3-O-rhamnopyranoside(7), and mangiferin(8). Compounds 1, 2 and 4-8 exhibited potent inhibitory effect on NO production in LPS-induced macrophages, especially compounds 6 and 8 showed the best inhibitory activity with IC50 values of 16.5 and 19.5 μmol·L-1, respectively. |
| Synonyms | 1,3,6-三没食子酰葡萄糖, 1,3,6-Tri-O-galloyl-β-D-glucose, 1,3,6-Tri-O-galloylglucose, 1,3,6-三-O-3,4,5-三羟基苯甲酰-BETA-D-葡萄糖 |
| molecular weight | 636.47 |
| Molecular formula | C27H24O18 |
| CAS | 18483-17-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Study on the anti-inflammatory active constituents of Mangifera indica L. seed kernel.Chinese Pharmaceutical Journal, 2015,50(19):1673-7. |
1,3,6-Tri-O-galloyl-beta-D-glucose
CAS No.: 18483-17-5
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound in Black Walnut Kernels. It shows
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