1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one-product

Description	1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) is the material basis for the analgesic effect of Dragons Blood.
In vitro	According to the operational definition of material basis for the efficacy of TCM established, the material basis of the modulation on the TTX-R sodium currents in DRG neurons of dragon??s blood was judged from the experimental results. The drug interaction equation of Greco et al. was used to assess the interaction of the three components extracted from dragon??s blood. This investigation demonstrated that dragon??s blood suppressed the peak TTX-R sodium currents in a dose-dependent way and affected the activations of TTX-R sodium currents. The effects of the combination of Cochinchinenin A, cochinchinenin B, and loureirin B were in good agreement with those of dragon??s blood. Although the three components used alone could modulate TTX-R sodium currents, the concentrations of the three components used alone were respectively higher than those used in combination when the inhibition rates on the TTX-R sodium currents of them used alone and in combination were the same. The combined effects of the three components were synergistic.
Synonyms	剑叶龙血素A, Cochinchinenin A
molecular weight	286.32
Molecular formula	C17H18O4
CAS	221696-69-1
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 50 mg/mL (174.63 mM)
References	1. Modulation of dragons blood on tetrodotoxin-resistant sodium currents in dorsal root ganglion neurons and identification of its material basis for efficacy Science in China Series C June 2006, Volume 49, Issue 3, pp 274-285

PeptideDB

1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

CAS No.: 221696-69-1