| Description | 1,2,3,6-Tetragalloylglucose (TeGG) has antioxidative activity, it also shows the most potent anticomplement activity (IC50 = 34 microM). 1,2,3,6-Tetragalloylglucose is also a potent inhibitor of UDP glucuronosyltransferase 1 A1 (UGT1A1, Ki = 1.68 μM). |
| In vitro | Two phenolics, 1,2,6-trigalloylglucose (1) and 1,2,3,6-Tetragalloylglucose (2), isolated from the stem-bark of Juglans mandshurica were evaluated for their antioxidative activities. The results showed that compounds 1 and 1,2,3,6-Tetragalloylglucose exhibited strong scavenging activities against 1,1'-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzenthiazoline-6-sulphonic) acid (ABTS(*+)), and superoxide radicals (O(2)(*-)), and also had a significant inhibitory effect on lipid peroxidation and low-density lipoprotein (LDL) oxidation[1] |
| Target activity | Anticomplement activity:34 microM, UGT1A1:1.68 μM(Ki) |
| Synonyms | 1,2,3,6-Tetra-O-galloyl-β-D-glucose, 1,2,3,6-四-O-没食子酰-Β-D-葡萄糖, TeGG |
| molecular weight | 788.57 |
| Molecular formula | C34H28O22 |
| CAS | 79886-50-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 91 mg/mL (115.40 mM) |
| References | 1. Ngoc TM, et al. Antioxidative activities of galloyl glucopyranosides from the stem-bark of Juglans mandshurica. Biosci Biotechnol Biochem. 2008 Aug;72(8):2158-63. 2. Park JB, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018 Oct;120:651-661. |