| Bioactivity | p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor[1][2][3]. | ||||||||||||
| Invitro | p-Aminophenylmercuric acetate (APMA) (0-30 µM；20 min) 减少了大鼠脑匀浆中二氢吗啡结合位点的数量，增加了激动剂对结合钠抑制作用的敏感性[2]。p-Aminophenylmercuric acetate (0.5 mM；30 min) 激活基质金属蛋白酶 2 和 9[3]。 | ||||||||||||
| Name | p-Aminophenylmercuric acetate | ||||||||||||
| CAS | 6283-24-5 | ||||||||||||
| Formula | C8H9HgNO2 | ||||||||||||
| Molar Mass | 351.75 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sanderson M P, et al. ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx[J]. Journal of Biological Chemistry, 2005, 280(3): 1826-1837. [2]. PASTERNAK G W, et al. Differential effects of protein-modifying reagents on receptor binding of opiate agonists and antagonists[J]. Molecular Pharmacology, 1975, 11(3): 340-351. [3]. Gendron R, et al. Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidine[J]. Clinical Diagnostic Laboratory Immunology, 1999, 6(3): 437-439. |
p-Aminophenylmercuric acetate
CAS: 6283-24-5 F: C8H9HgNO2 W: 351.75
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric
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