| Bioactivity | mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability[1]. | ||||||||||||
| In Vivo | In vivo, mGluR2 antagonist 1 (Compound 25) reverses the effect of mGluR2 agonist LY379268 in amphetamine-induced hyperlocomotion and shows good efficacy in the mouse delayed non-match to position assay at 10 mg/kg. | ||||||||||||
| Name | mGluR2 antagonist 1 | ||||||||||||
| CAS | 1432728-49-8 | ||||||||||||
| Formula | C21H16FN3O3 | ||||||||||||
| Molar Mass | 377.37 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Youheng Shu,et al. Discovery of 4-arylquinoline-2-carboxamides, Highly Potent and Selective Class of mGluR2 Negative Allosteric Modulators: From HTS to Activity in Animal Models. Bioorg Med Chem Lett. 2020 May 1;30(9):127066. |
mGluR2 antagonist 1
CAS: 1432728-49-8 F: C21H16FN3O3 W: 377.37
mGluR2 antagonist 1 is ahighly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (
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