| Bioactivity | hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with IC50 values of 37.88 and 45.23 nM, respectively. hCAI/II-IN-5 also shows inhibition profile against α-Glycosidase and AChE, with IC50 values of 48.98 and 420.14 nM, respectively. hCAI/II-IN-5 can be used for the research of many diseases such as diabetes, Alzheimer’s disease, heart failure, ulcer, and epilepsy[1]. |
| Target | IC50: 37.88 ± 0.9956 nM (hCA II), 45.23 ± 0.9684 nM (hCA I), 48.98 ± 0.9407 nM (α-GLY), 420.14 ± 0.9759 nM (AChE); KI: 40.35 ± 5.74 nM (hCA II), 50.04 ± 5.76 nM (α-GLY), 51.67 ± 4.76 nM (hCA I), 363.96 ± 32.87 nM (AChE) |
| Name | hCAI/II-IN-5 |
| CAS | 2428389-67-5 |
| Formula | C21H18Cl2N8O4S2 |
| Molar Mass | 581.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lolak N, et al. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorg Ch |
hCAI/II-IN-5
CAS: 2428389-67-5 F: C21H18Cl2N8O4S2 W: 581.45
hCAI/II-IN-5 (compound MZ8) is a potent hCA I and hCA II (human carbonic anhydrase isoenzymes I and II) inhibitor, with
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This product is for research use only, not for human use. We do not sell to patients.