Bioactivity | hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE, MAO-B-IN-1 and BACE-1 inhibitor, with IC50 values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease[1]. |
Invitro | hAChE-IN-3 (compounds 5c) 对 SH-SY5Y 细胞系的 IC50 值为 36.28 μM(24 h),对 HepG2 细胞系的IC50 值为 154.10 μM(48 h)[1]。hAChE-IN-3 对 β - 淀粉样斑块聚集的 IC50 值为2.58 μM,抑制率为59% (10 μM)[1]。 0 --> hAChE-IN-3 相关抗体: |
Name | hAChE-IN-3 |
Formula | C30H24ClN3O5 |
Molar Mass | 541.98 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Salma Fares,et al. Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’sDisease: Synthesis, Biological Evaluation, and Molecular Modeling Study. ACS Omega 2023, 8, 29, 26012–26034. |