| Bioactivity | exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway[1][2]. | ||||||||||||
| Invitro | exo-IWR-1 (10 μM) does not influence the number of 293T cells infected with bunyaviruses[1].Exo-IWR-1 had no effect on RVFV MP12-GFP infection when cells were either pretreated or treated 1 hpi[2]. | ||||||||||||
| Name | exo-IWR-1 | ||||||||||||
| CAS | 1127442-87-8 | ||||||||||||
| Formula | C25H19N3O3 | ||||||||||||
| Molar Mass | 409.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Brooke Hamion, et al. Genome-wide RNA Interference Screen Identifies Novel Drug Targets for Rift Valley Fever Virus That Minimi the Potential for Drug Resistance. [2]. Brooke Harmon, et al. A Genome-Wide RNA Interference Screen Identifies a Role for Wnt/β-Catenin Signaling during Rift Valley Fever Virus Infection. J Virol. 2016 Jul 27;90(16):7084-7097. |
exo-IWR-1
CAS: 1127442-87-8 F: C25H19N3O3 W: 409.44
exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control ofIWR-1 (HY-12238). IWR-1 is a tankyrase inhibi
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