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Bioactivity cycFWRPW is a peptide inhibitor of TLE1. TLE1 is an oncogenic transcriptional co‐repressor that exerts its repressive effects through binding of transcription factors[1].
CAS 2116533-34-5
Sequence Phe-Trp-Arg-Pro-Trp (covalent bridge:Trp2-Pro4)
Shortening FWRPW (covalent bridge:Trp2-Pro4)
Formula C46H56N10O6
Molar Mass 845.00
Transport Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. McGrath S, et al. Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1. Chemistry. 2017 Jul 18;23(40):9577-9584.

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