Zoledronic Acid_product_DataBase

Bioactivity	Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects[1].
Invitro	Zoledronic Acid (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells[2].Zoledronic Acid increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells[2].Zoledronic Acid enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells[2].Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways[3].Zoledronic Acid (10-100 µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells[4].Zoledronic Acid (10-100 µM; 1-7 days) induces apoptosis in MC3T3-E1 cells[4].Zoledronic Acid (10-100 µM; 4 days) inhibits cell viability due to the induction of apoptosis[4].Zoledronic Acid exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 µM[4]. Cell Viability Assay[4] Cell Line:
Name	Zoledronic Acid
CAS	118072-93-8
Formula	C5H10N2O7P2
Molar Mass	272.09
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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