PeptideDB

Zimelidine

CAS: 56775-88-3 F: C16H17BrN2 W: 317.22

Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant.
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Bioactivity Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant[1][2][3][4].
In Vivo Zimelidine (15 mg/kg, IP, once) reduces the development of tolerance to morphine-induced antinociception in rats[3].Zimelidine (5 mg/kg, IP, daily for 14 days) dose not modify the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT[2].Zimelidine (0.2, 2 and 20 nmol/100 nL) in medial amygdaloid nucleus (MeA) evokes dose dependent hypophagic effects in fasted rats[4]. Animal Model:
Name Zimelidine
CAS 56775-88-3
Formula C16H17BrN2
Molar Mass 317.22
Transport Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Reference [1]. Heel RC, et al. Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1982 Sep;24(3):169-206. [2]. Blier P, et al. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci. 1983 Jun;3(6):1270-8. [3]. Ozdemir E, et al. Zimelidine attenuates the development of tolerance to morphine-induced antinociception. Indian J Pharmacol. 2012 Mar;44(2):215-8. [4]. Scopinho AA, et al. Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats. Neuropharmacology. 2012 Aug;63(2):301-9.