| Bioactivity | Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma[1][2][3]. | ||||||||||||
| Invitro | Zardaverine (0-30 µM; 72 h) selectively inhibits the growth of human HCC cells in vitro[1].Zardaverine shows selective antitumor activity that closely related to the regulation of cell cycle-associated proteins, but is independent of PDE3/4 inhibition[1].Zardaverine (0.1 µM; 24 h) selectively causes G0/G1-phase arrest and dysregulates cell cycle-associated proteins in HCC cells[1].Zardaverine (0.01, 0.03, 0.1, 0.3 1 µM/48h; 0.3 1 µM/24, 36, 48, 60, 72 h) induces apoptosis in a time- and concentration- dependent manner, in Bel-7402 and SMMC-7721 cells[1]. Cell Proliferation Assay[1] Cell Line: | ||||||||||||
| Name | Zardaverine | ||||||||||||
| CAS | 101975-10-4 | ||||||||||||
| Formula | C12H10F2N2O3 | ||||||||||||
| Molar Mass | 268.22 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Zardaverine
CAS: 101975-10-4 F: C12H10F2N2O3 W: 268.22
Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activi
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