| Bioactivity | Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1]. |
| Invitro | Zabofloxacin shows a highly potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC90: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC90: 1 mg/L) is more active than ciprofloxacin, sparfloxacin, and moxifloxacin[1]. |
| Name | Zabofloxacin hydrochloride |
| CAS | 623574-00-5 |
| Formula | C19H21ClFN5O4 |
| Molar Mass | 437.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Zabofloxacin hydrochloride
CAS: 623574-00-5 F: C19H21ClFN5O4 W: 437.85
Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of thebacterial type II and IV topoisomerases. Z
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