| Bioactivity | ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia[1][3]. |
| Invitro | ZP 120C (1 nM) inhibits electrically induced contraction of the mouse vas deferen[2].ZP 120C (1 μM) inhibits electrical field stimulation (EFS)-induced contractions in rat arteries[3]. |
| In Vivo | ZP 120C (1 nM/kg/min, i.v., 2.5 h) displays an aquaretic effect in conscious, chronically instrumented rats with congestive heart failure (CHF)[1].ZP 120C (1 nM, i.c.v., 30 min) produces pronociceptive effects in the tail withdrawal assay and decreases locomotor activity in mice[2]. Animal Model: |
| Name | ZP 120C |
| CAS | 383123-18-0 |
| Shortening | Ac-RYYRWKKKKKKK-NH2 |
| Formula | C85H |
| Molar Mass | 1781.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hadrup N, et al. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. Am J Physiol Renal Physiol. 2004 Jul;287(1):F160-8. [2]. Rizzi A, et al. Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice. Br J Pharmacol. 2002 Oct;137(3):369-74. [3]. Simonsen U, et al. ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries. Br J Pharmacol. 2008 Mar;153(6):1185-94. |