| Bioactivity | Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells[1]. |
| Sequence | (Z-Ile-Glu-Thr-Asp)2-Rhodamine 110 |
| Shortening | (Z-IETD)2-Rhodamine 110 |
| Formula | C74H86N10O25 |
| Molar Mass | 1515.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Baumgartner H K, et al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2007, 293(1): G296-G307. |