| Bioactivity | Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine[1]. |
| Target | α2-adrenergic |
| In Vivo | Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment[1]. Animal Model: |
| Name | Xylazine hydrochloride |
| CAS | 23076-35-9 |
| Formula | C12H17ClN2S |
| Molar Mass | 256.79 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Shi XX, et al. Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the CentralNervous System of Rats. PLoS One. 2016 Apr 6;11(4):e0153169. |
Xylazine hydrochloride
CAS: 23076-35-9 F: C12H17ClN2S W: 256.79
Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimul
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