| Bioactivity | Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation[1][2]. |
| Invitro | Xanthoxyletin (1-500 µM；30 分钟) 抑制 DPPH 自由基的 IC50 值为 247.1 μM 和 63.8 μg/mL，对铁还原抗氧化能力 (FRAP) 的值为 45.2 μM[2]。Xanthoxyletin (10-500µM；24 小时) 对 HepG2，HCT116 和 SK-LU-1 癌细胞具有细胞毒性，IC50 值分别为 78.2，79.8 和 94.4 μM[2]。Xanthoxyletin (78 和 156 μM；12 和 24 小时) 诱导细胞凋亡，引起低坏死[2]。 Cell Cytotoxicity Assay[2] Cell Line: |
| Name | Xanthoxyletin |
| CAS | 84-99-1 |
| Formula | C15H14O4 |
| Molar Mass | 258.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |