| Bioactivity | Vatinoxan (MK-467; L-659066) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan determines that it has limited penetration across the blood-brain barrier and therefore has low concentrations in the central nervous system. Vatinoxan antagonizes alpha 2-adrenergic receptor receptors by binding to them, thereby reducing or preventing cardiovascular effects caused by α2-adrenergic agonists. Vatinoxan can be used in studies of cardiovascular effects, sedation and analgesia[1]. |
| CAS | 114914-42-0 |
| Formula | C20H26N4O4S |
| Molar Mass | 418.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Honkavaara J M, et al. Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs[J]. Veterinary anaesthesia and analgesia, 2020, 47(1): 47-52. |
Vatinoxan
CAS: 114914-42-0 F: C20H26N4O4S W: 418.51
Vatinoxan (MK-467; L-659066) is an alpha 2-adrenergic receptor antagonist. The peripheral selectivity of Vatinoxan deter
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